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Основная причина — нарушение действия **антидиуретического гормона вазопрессина**, который регулирует процесс выведения жидкости через почки [5](https://genez.by/diagnoses/nesaharnyj-diabet/). В результате человек выделяет чрезмерное количество мочи и постоянно испытывает сильную жажду, даже если пьёт много воды [5](https://genez.by/diagnoses/nesaharnyj-diabet/). \n\nЗаболевание диагностируется в любом возрасте, но чаще всего его выявляют у людей 20–40 лет независимо от пола [1](https://alfazdrav.ru/zabolevania/endokrinologiya/nesakharnyy-diabet/).\n\n\n\n## Причины\nНекоторые типы несахарного диабета: \n* **Центральный** — нарушение выработки вазопрессина в головном мозге [5](https://genez.by/diagnoses/nesaharnyj-diabet/). Причиной могут быть травмы, опухоли, хирургические вмешательства, инфекции или воспаления в области гипоталамуса и гипофиза [5](https://genez.by/diagnoses/nesaharnyj-diabet/). \n* **Почечный (нефрогенный)** — почки теряют чувствительность к вазопрессину [5](https://genez.by/diagnoses/nesaharnyj-diabet/). Гормон вырабатывается нормально, но почечные рецепторы на него не реагируют [5](https://genez.by/diagnoses/nesaharnyj-diabet/). \n* **Гестационный** — возникает у беременных женщин, когда плацента вырабатывает ферменты, разрушающие вазопрессин [6](https://www.MedCentrServis.ru/disease/nesaharnyj-diabet/). Как правило, гестационный несахарный диабет — временное состояние и проходит после родов, но в некоторых случаях может привести к стойкому водному дисбалансу [6](https://www.MedCentrServis.ru/disease/nesaharnyj-diabet/).\n\n## Симптомы\nНекоторые проявления несахарного диабета: \n* **Полидипсия** — повышенное чувство жажды, человек пьёт много жидкости, иногда до 20 литров в день [11](https://HimkiMed.ru/zabolevaniya/nesakharnyy-diabet.html). \n* **Частое мочеиспускание (полиурия)** — выделение большого объёма разбавленной мочи днём и ночью [11](https://HimkiMed.ru/zabolevaniya/nesakharnyy-diabet.html). \n* **Сухость кожи и слизистых** [11](https://HimkiMed.ru/zabolevaniya/nesakharnyy-diabet.html). \n* **Повышенная усталость и слабость** [11](https://HimkiMed.ru/zabolevaniya/nesakharnyy-diabet.html). \n* **Нарушение сна** из-за частых ночных походов в туалет [11](https://HimkiMed.ru/zabolevaniya/nesakharnyy-diabet.html). \n* **Потеря массы тела** [11](https://HimkiMed.ru/zabolevaniya/nesakharnyy-diabet.html). \n\nЕсли организм не успевает восполнять потери жидкости, развиваются признаки обезвоживания: сухость кожи и слизистых, снижение слюноотделения, слабость, головокружение [12](https://fomin-clinic.ru/zabolevaniya/nesakharnyy-diabet/).\n\n## Диагностика\nПри подозрении на несахарный диабет необходимо обратиться к терапевту, а после первичного обследования — к эндокринологу [1](https://alfazdrav.ru/zabolevania/endokrinologiya/nesakharnyy-diabet/). Некоторые методы диагностики: \n* **Лабораторные исследования**: общий анализ мочи, анализ крови, тест с водной нагрузкой (пациент выпивает определённое количество воды, после чего в течение нескольких часов регулярно измеряется объём мочи и её концентрация) [11](https://HimkiMed.ru/zabolevaniya/nesakharnyy-diabet.html). \n* **Инструментальные методы**: МРТ гипофиза и гипоталамуса, УЗИ почек [13](https://www.yamed.ru/services/endokrinologiya/nesaharny-diabet/).\n\n## Лечение\nТактика лечения зависит от типа несахарного диабета [14](https://gemotest.ru/info/spravochnik/zabolevaniya/nesakharnyy-diabet/): \n* **Медикаментозная терапия**: при центральном типе назначают препараты синтетического аналога гормона вазопрессина — десмопрессина [14](https://gemotest.ru/info/spravochnik/zabolevaniya/nesakharnyy-diabet/). 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