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Протекает с нарастающим распадом личности, аффективными, бредовыми и неврологическими (параличи) расстройствами, завершается тотальным слабоумием и маразмом [2](https://old.bigenc.ru/medicine/text/3179101). \n\nВпервые заболевание описал и выделил как самостоятельное А. Бейль (1822) [2](https://old.bigenc.ru/medicine/text/3179101). Сифилитическое поражение ЦНС как причину прогрессивного паралича установил в 1913 году Х. Ногучи [2](https://old.bigenc.ru/medicine/text/3179101).\n\n## Причины\nВозбудитель сифилиса — **бледная трепонема** [3](https://yandex.ru/medicine/disease/progressivnyj-paralich)[5](https://www.KrasotaiMedicina.ru/diseases/zabolevanija_neurology/Bayle). Занос инфекционного агента в церебральные ткани происходит гематогенным и лимфогенным путём [5](https://www.KrasotaiMedicina.ru/diseases/zabolevanija_neurology/Bayle). \n\nПрогрессивный паралич встречается у 1–5% больных сифилисом, пик заболеваемости — 35–50 лет [5](https://www.KrasotaiMedicina.ru/diseases/zabolevanija_neurology/Bayle). Временной диапазон развития симптоматики — от 3 до 30 лет с момента инфицирования, чаще — 10–15 лет [5](https://www.KrasotaiMedicina.ru/diseases/zabolevanija_neurology/Bayle).\n\n## Симптомы\nВ течении прогрессивного паралича обычно выделяют три стадии [2](https://old.bigenc.ru/medicine/text/3179101): \n1. **Начальные проявления** — возникают спустя 10–15 лет после заражения сифилисом, проявляются астенией, слабодушием, раздражительностью, снижением памяти, умеренно выраженными тревожно-депрессивными, ипохондрическими и бредовыми расстройствами (бред ревности, преследования, отравления и др.) [2](https://old.bigenc.ru/medicine/text/3179101). \n2. **Вторая стадия** — может протекать в нескольких формах: классической экспансивной (сочетание маниакального возбуждения с бредом величия), дементной (нарастающее слабоумие, нелепое поведение, бездеятельная эйфория) и др. [2](https://old.bigenc.ru/medicine/text/3179101). Для всех форм характерны быстро нарастающее слабоумие, множественные параличи и глазные неврологические симптомы — поражение зрачков в виде отсутствия реакций на свет при сохранности реакций на конвергенцию и аккомодацию [2](https://old.bigenc.ru/medicine/text/3179101). \n3. **Третья стадия (маразма)** — прекращается сознательная деятельность, исчезает речь, больные не могут передвигаться и обычно погибают от интеркуррентных (привходящих, случайных) заболеваний [2](https://old.bigenc.ru/medicine/text/3179101).\n\n## Диагностика\nДля диагностики прогрессивного паралича проводят следующие обследования [3](https://yandex.ru/medicine/disease/progressivnyj-paralich): \n* **Неврологический осмотр** и нейропсихологическое тестирование [3](https://yandex.ru/medicine/disease/progressivnyj-paralich). \n* **Лабораторная диагностика** — трепонемные тесты крови (реакция Вассермана, RPR-тест) [3](https://yandex.ru/medicine/disease/progressivnyj-paralich). \n* **Исследование цереброспинальной жидкости** — ликвор получают путём люмбальной пункции [3](https://yandex.ru/medicine/disease/progressivnyj-paralich). \n* **МРТ головного мозга** — в зависимости от фазы болезни выявляет диффузные воспалительные или атрофические изменения, затрагивающие оболочки, вещество мозга и эпендиму желудочков [3](https://yandex.ru/medicine/disease/progressivnyj-paralich).\n\n## Лечение\nЛечение прогрессивного паралича осуществляется комплексно пирогенными, антитрепонемными, психокорригирующими, нейрометаболическими препаратами [5](https://www.KrasotaiMedicina.ru/diseases/zabolevanija_neurology/Bayle). \n\n**Профилактика** — своевременное лечение сифилиса [2](https://old.bigenc.ru/medicine/text/3179101).","linksData":[{"sourceId":1,"url":"https://ru.wikisource.org/wiki/%D0%AD%D0%A1%D0%91%D0%95/%D0%9F%D1%80%D0%BE%D0%B3%D1%80%D0%B5%D1%81%D1%81%D0%B8%D0%B2%D0%BD%D1%8B%D0%B9_%D0%BF%D0%B0%D1%80%D0%B0%D0%BB%D0%B8%D1%87","shownUrl":"https://ru.wikisource.org/wiki/%D0%AD%D0%A1%D0%91%D0%95/%D0%9F%D1%80%D0%BE%D0%B3%D1%80%D0%B5%D1%81%D1%81%D0%B8%D0%B2%D0%BD%D1%8B%D0%B9_%D0%BF%D0%B0%D1%80%D0%B0%D0%BB%D0%B8%D1%87","title":"ЭСБЕ/Прогрессивный паралич — Викитека","shortUrl":"ru.wikisource.org","isTranslated":false,"description":"","greenUrl":"ru.wikisource.org"},{"sourceId":2,"url":"https://old.bigenc.ru/medicine/text/3179101","shownUrl":"https://old.bigenc.ru/medicine/text/3179101","title":"ПРОГРЕССИВНЫЙ ПАРАЛИЧ • Большая российская энциклопедия - электронная версия","shortUrl":"old.bigenc.ru","isTranslated":false,"description":"","greenUrl":"old.bigenc.ru"},{"sourceId":3,"url":"https://yandex.ru/medicine/disease/progressivnyj-paralich","shownUrl":"https://yandex.ru/medicine/disease/progressivnyj-paralich","title":"Прогрессивный паралич - симптомы, причины и лечение","shortUrl":"yandex.ru","isTranslated":false,"description":"","greenUrl":"yandex.ru"},{"sourceId":4,"url":"https://www.invitro.ru/library/bolezni/34712/","shownUrl":"https://www.invitro.ru/library/bolezni/34712/","title":"Нейросифилис - причины появления, симптомы заболевания, диагностика и способы лечения","shortUrl":"invitro.ru","isTranslated":false,"description":"","greenUrl":"invitro.ru"},{"sourceId":5,"url":"https://www.KrasotaiMedicina.ru/diseases/zabolevanija_neurology/Bayle","shownUrl":"https://www.KrasotaiMedicina.ru/diseases/zabolevanija_neurology/Bayle","title":"Прогрессивный паралич - причины, симптомы, диагностика и лечение","shortUrl":"KrasotaiMedicina.ru","isTranslated":false,"description":"","greenUrl":"KrasotaiMedicina.ru"},{"sourceId":6,"url":"https://raduga163.com/articles/progressivnyj-paralich-bolshaya-meditsinskaya-entsiklopediya","shownUrl":"https://raduga163.com/articles/progressivnyj-paralich-bolshaya-meditsinskaya-entsiklopediya","title":"Прогрессивный паралич (Бейля болезнь): диагноз, характерные проявления, эффективное лечение","shortUrl":"raduga163.com","isTranslated":false,"description":"","greenUrl":"raduga163.com"},{"sourceId":7,"url":"https://psychiatry.ru/lib/54/book/31/chapter/55","shownUrl":"https://psychiatry.ru/lib/54/book/31/chapter/55","title":"ФГБНУ НЦПЗ. 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