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Заболевание имеет хронический характер, периоды желтухи и ремиссии чередуются [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera)[5](https://polyclinika.ru/tech/sindrom-zhilbera-simptomy-diagnostika-lechenie/). \n\nНазвание происходит от имени французского врача Августина Николя Жильбера, который впервые описал это состояние в начале XX века [3](https://voronezh.sovamed.ru/zabolevaniya/sindrom-zhilbera/).\n\n\n\n## Причины\nОсновная причина — **генетическая мутация гена UGT1A1** [3](https://voronezh.sovamed.ru/zabolevaniya/sindrom-zhilbera/)[5](https://polyclinika.ru/tech/sindrom-zhilbera-simptomy-diagnostika-lechenie/). Дефект приводит к нарушению продукции печёночного фермента УДФГТ1, который отвечает за метаболизм билирубина [6](https://www.smclinic-spb.ru/zabolevaniya/sindrom-zhilbera). \n\nЗаболевание передаётся по наследству, тип наследования — аутосомно-доминантный [6](https://www.smclinic-spb.ru/zabolevaniya/sindrom-zhilbera).\n\n## Симптомы\n**Основной признак** — пожелтение кожи, склер глаз, слизистых [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera)[10](https://mrtshka.ru/articles/sindrom-zhilbera-simptomy-diagnostika-lechenie/). \n\n**Другие симптомы**: \n* дискомфорт и ощущение тяжести в правом подреберье [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera); \n* отрыжка, тошнота [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera); \n* вздутие живота, нарушения работы ЖКТ, жидкий стул [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera); \n* слабость, недомогание [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera); \n* ухудшение аппетита [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera); \n* бессонница, нервозность, раздражительность [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera). \n\nПримерно у 1/3 пациентов болезнь протекает бессимптомно [2](https://Megapteka.ru/specials/kak-proyavlyaetsya-sindrom-448).\n\n## Диагностика\n**При признаках желтухи и других неприятных симптомах необходимо обратиться к терапевту**, детям и подросткам — к педиатру [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera). Он назначит базовые диагностические мероприятия и на основании их результатов направит пациента к специалистам — гепатологу, генетику, при необходимости — гастроэнтерологу [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera). \n\n**Для установления диагноза** проводят общий анализ крови и мочи, функциональные пробы печени, исследование биохимического состава желчи, генетическое тестирование, морфологическое исследование ткани печени [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera).\n\n## Лечение\n**Специфических методик при синдроме Жильбера нет** [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera). Как правило, назначают препараты, нормализующие состав желчи и стимулирующие её отделение, и средства для улучшения работы печени [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera). Также рекомендуется придерживаться специальной диеты [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera). \n\n**Полностью избавиться от синдрома Жильбера нельзя**, но необходимо контролировать состояние и выполнять рекомендации, чтобы избежать повышения билирубина и проявлений желтухи [4](https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera).","linksData":[{"sourceId":1,"url":"https://unionclinic.ru/sindrom-zhilbera/","shownUrl":"https://unionclinic.ru/sindrom-zhilbera/","title":"Синдром Жильбера | Справочник ЮНИОН КЛИНИК","shortUrl":"unionclinic.ru","isTranslated":false,"description":"","greenUrl":"unionclinic.ru"},{"sourceId":2,"url":"https://Megapteka.ru/specials/kak-proyavlyaetsya-sindrom-448","shownUrl":"https://Megapteka.ru/specials/kak-proyavlyaetsya-sindrom-448","title":"Синдром Жильбера: Что это такое простыми словами, симптомы и лечение","shortUrl":"Megapteka.ru","isTranslated":false,"description":"","greenUrl":"Megapteka.ru"},{"sourceId":3,"url":"https://voronezh.sovamed.ru/zabolevaniya/sindrom-zhilbera/","shownUrl":"https://voronezh.sovamed.ru/zabolevaniya/sindrom-zhilbera/","title":"Синдром Жильбера: причины, симптомы, диагностика и лечение | Клиника «СОВА» Воронеж","shortUrl":"voronezh.sovamed.ru","isTranslated":false,"description":"","greenUrl":"voronezh.sovamed.ru"},{"sourceId":4,"url":"https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera","shownUrl":"https://www.VIDAL.ru/encyclopedia/gastroenterologiya/sindrom-zhilbera","title":"Синдром Жильбера - 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