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Это приводит к повреждению ворсинок тонкого кишечника, что нарушает всасывание питательных веществ [4](https://www.kdpmc.ru/zabolevaniya/celiakiya/)[7](https://gemotest.ru/info/spravochnik/zabolevaniya/tseliakiya/). \n\nЗаболевание может развиваться в любом возрасте, но чаще всего проявляется в детском или в раннем взрослом [5](https://doct.ru/diseases/celiakiya.html).\n\n\n\n## Причины\n**Основная причина** — генетическая предрасположенность [5](https://doct.ru/diseases/celiakiya.html). У людей с генами HLA-DQ2 и HLA-DQ8 повышен риск развития целиакии, но наличие этих генов не всегда приводит к возникновению заболевания [5](https://doct.ru/diseases/celiakiya.html). \n\n**Фактор риска** — семейная предрасположенность: если у одного из родственников первой линии диагностирована целиакия, риск заболевания у остальных членов семьи возрастает [5](https://doct.ru/diseases/celiakiya.html). \n\n**Пусковым фактором** у людей с генетической предрасположенностью могут стать стрессовые ситуации: эмоциональное потрясение, беременность или хирургическое вмешательство [7](https://gemotest.ru/info/spravochnik/zabolevaniya/tseliakiya/).\n\n## Симптомы\n**Некоторые проявления целиакии**: \n* хроническая диарея, которая может сопровождаться слизью или жировыми включениями [4](https://www.kdpmc.ru/zabolevaniya/celiakiya/); \n* болезненное вздутие живота, метеоризм — избыточное газообразование [4](https://www.kdpmc.ru/zabolevaniya/celiakiya/); \n* снижение аппетита, слабость, утомляемость [4](https://www.kdpmc.ru/zabolevaniya/celiakiya/); \n* часто развивается анемия из-за дефицита железа [4](https://www.kdpmc.ru/zabolevaniya/celiakiya/). \n\n**У некоторых людей** целиакия может протекать бессимптомно или с минимальными проявлениями [13](https://www.mos-clinics.ru/diseases/tseliakiya/).\n\n## Диагностика\n**Диагностика целиакии включает несколько этапов** [13](https://www.mos-clinics.ru/diseases/tseliakiya/): \n* **Серологические тесты** — анализ крови на наличие специфических антител к тканевой трансглутаминазе, антител к деамидированному глиадину и антител к эндомизию [13](https://www.mos-clinics.ru/diseases/tseliakiya/). Высокий уровень этих антител может указывать на целиакию [13](https://www.mos-clinics.ru/diseases/tseliakiya/). \n* **Генетическое тестирование** — определение наличия генов HLA-DQ2 и HLA-DQ8 может помочь выявить предрасположенность к целиакии, но не является самостоятельным методом диагностики [13](https://www.mos-clinics.ru/diseases/tseliakiya/). \n* **Эндоскопия с биопсией тонкого кишечника** — «золотой стандарт» диагностики целиакии, эндоскопическое исследование верхних отделов желудочно-кишечного тракта с взятием нескольких образцов слизистой оболочки тонкого кишечника (биопсия) [13](https://www.mos-clinics.ru/diseases/tseliakiya/).\n\n## Лечение\n**Основной метод лечения** — **пожизненное соблюдение строгой безглютеновой диеты** [13](https://www.mos-clinics.ru/diseases/tseliakiya/). Это означает полное исключение из рациона всех продуктов, содержащих пшеницу, рожь, ячмень и их производные (например, манную крупу, перловку, булгур, кускус, полбу) [13](https://www.mos-clinics.ru/diseases/tseliakiya/). \n\n**Помимо соблюдения диеты**, пациентам с целиакией может потребоваться дополнительная терапия для устранения дефицита питательных веществ [13](https://www.mos-clinics.ru/diseases/tseliakiya/). 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