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İsviçre'nin Bern bölgesinde yaşayan alerji hastaları ve sağlıklı kontrollerin doğal immün yanıtları karşılaştırmalı olarak analiz edilmekte, inne-lenfoid hücreler, monositler ve dentritik hücrelerdeki değişimler zaman içinde değerlendirilmektedir.","Sunumda alerjen immünoterapisinin ilk bir yıl boyunca in-lenfoid alt kümelerinin sıklık ve sayı değerlerini, CD25 ve CD14-16 ekspresyonlarındaki değişiklikleri, pro-inflamatuar hücrelerde azalma ve anti-inflamatuar popülasyonunda artış yarattığı, plazmatikoid entetik hücrelerin artışı ve miyeloid dentritik hücrelerin azalması gibi bulgular detaylı olarak açıklanmaktadır. Sunum, alerjen immünoterapisinin üç yıla kadar sabit kalması ve sistemik doğal immün hücreleri repertuarını sağlıklı bir kişinin immün durumuna getirmesi gibi önemli noktaları vurgulamaktadır."]},"endTime":2884,"title":"Alerjen Spesifik İmmünoterapide Doğal Bağışıklık Sisteminin Rolü","beginTime":0}],"fullResult":[{"index":0,"title":"Sunum ve Makale Tanıtımı","list":{"type":"unordered","items":["Candan, Jaki dergisinde yayınlanma aşamasında olan \"Alerjen Spesifik İmmünoterapide İnne-Lenfoid Hücreler, Monositler ve Dentritik Hücrelerde Gelişen Eğitilmiş Immünce ve Tolerans\" adlı makalesini sunacak.","Makale, alerjik hastalar ve sağlıklı kontrollerin belirli bir süreçte prospektif olarak izlenmesiyle başlayıp, alerjen immünoterapiye bağlı değişikliklerin sağlıklı kontrolleri ile karşılaştırmasını anlatıyor."]},"beginTime":53,"endTime":131,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=53&ask_summarization=1"},{"index":1,"title":"Alerjen İmmünoterapinin Tarihçesi","list":{"type":"unordered","items":["Alerjen immünoterapide ilk girişimler önleyici aşılarla 1800'lü yıllarda Edward Jenner, Louis Pasteur, Robert Cord ve Adolf Behring tarafından uygulanmıştır.","1900 yılında Curtis Ragvit polenlerin sulu ekstrelerini hastalara uyguladığında semptomlarda azalma fark etmiştir.","1916 yılında Robert Cook immünoterapinin ilk temelini atmış, 1966 yılında ise Aka ve arkadaşlarının immünglobilin E'yi keşfetmesiyle immünoterapinin esas günümüzdeki anlamıyla keşfi başlamıştır."]},"beginTime":131,"endTime":212,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=131&ask_summarization=1"},{"index":2,"title":"Alerjen İmmünoterapisinin Günümüzdeki Durumu","list":{"type":"unordered","items":["Günümüzde alerjen immünoterapisi alerjik rinit ve alerjik astım gibi alerjik hastalıkları olan hastalar için nedene yönelik olan ve hastalık seyrini değiştirilebilen tek tedavi yöntemidir.","Hastanın klinik olarak duyarlı olduğu gösterilmiş antijen alerjen ekstresinin düşük dozdan başlayarak giderek artan ve yan etki oluşturmayan dozlarda uzun süreli uygulanmasıyla yapılır.","Bu tedavi, humoral ve hücresel efektörlerin baskılanmasına aracılık eder."]},"beginTime":212,"endTime":247,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=212&ask_summarization=1"},{"index":3,"title":"Alerji Mekanizması ve Alerjen İmmünoterapisi","list":{"type":"unordered","items":["Alerjenlerin dendritik hücrelerle naif T hücrelerinin sunulması sonrasında Tp2 hücreleri aktive olur ve interleukin-3, interleukin-4, interleukin-5, interleukin-9, interleukin-13 gibi sitokinler efektör alerji hücrelerini aktive eder.","Alerjen immünoterapisinde T hücreleri uyarılarak interleukin-10 ve TGF-beta anti-inflamatuar sitokinleri salgılanır, bu sitokinler mast hücreleri, bazofil ve ezofiller gibi hücrelerin erken desensitasyonunu önler.","Alerjen immünoterapisinde amaç periferik tolerans mekanizmalarını kullanarak alerjenlere karşı uzun süreli klinik tolerans sağlamaktır."]},"beginTime":247,"endTime":442,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=247&ask_summarization=1"},{"index":4,"title":"Doğal İmmün Sistem ve Hücreler","list":{"type":"unordered","items":["Doğal immün sistem, innate lenfoid hücreler, natural killer (doğal öldürücü) hücreler, monosit, makrofajlar ve dendritik hücrelerden oluşur.","Innate lenfoid hücreler, antimikrobiyal yanıtın, doku onarımının ve epitel bütünlüğünün korunmasının erken safhasında önemli işlev görür ve üç alt gruba ayrılır.","Natural killer hücreleri, T hücreleri ile bazı işlevsel benzerliklere sahiptir ve dolaşımdaki NK hücreleri yüzeyi markalarına göre iki gruba ayrılır."]},"beginTime":442,"endTime":540,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=442&ask_summarization=1"},{"index":5,"title":"Monosit ve Dentritik Hücreler","list":{"type":"unordered","items":["Monosit ve dendritik hücreler antijen sunan hücrelerdir ve doğal ve adaptif immün yanıtı birbirine bağlamada yardımcı olurlar.","Monositler CD14 ve CD16 ekspresyondaki farklılıklarına göre klasik, intermedit ve non-klasik olmak üzere üç farklı alt gruba ayrılır.","Non-klasik monositler pro-inflamatuar hücrelerdir, intermediate monositler anti-inflamatuar olarak adlandırılır ve klasik monositler antistik hücrelere farklılaşabilen gruptur."]},"beginTime":540,"endTime":631,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=540&ask_summarization=1"},{"index":6,"title":"Dendrit Hücre Alt Grupları","list":{"type":"unordered","items":["Dendrit hücreler üç ana alt gruba ayrılır: plazmatik dendritik hücreler, CD303 pozitif dendritik hücreler ve CD1C ve CD141 pozitif dendritik hücreler.","Plazmatik dendritik hücreler olgunlaşmamış bir dendritik hücre formu olarak kabul edilirken, CD1C ve CD141 pozitif dendritik hücreler hem olgunlaşmamış dendritik hücrelerin hem de CD303 pozitif dendritik hücrelerin öncüllerinin özelliklerini gösterir.","Niyale dendritik hücrelerin esas olarak T-helper 2 yanıtlarının geliştirilmesinde rol oynadığı, plazmatik dendritik hücrelerin antiviral yanıtları indükleyebileceği veya regülatör T hücrelerin indüksiyonu ile tolerans gelişimini düzenleyebileceği öne sürülmüştür."]},"beginTime":643,"endTime":690,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=643&ask_summarization=1"},{"index":7,"title":"Çalışmanın Yöntemi","list":{"type":"unordered","items":["Çalışmada, huş ağacı ve çimen polenleri için sezon öncesi subkutan alerjen immünoterapi sırasında çeşitli zaman noktalarında sistemik doğal immün yanıtlardaki dinamik değişiklikler analiz edilmiştir.","Hastalar İsviçre'nin Bern bölgesinde yaşayan ve çimen ve veya huş ağacı polenine karşı alerjisi olan kişiler, sağlıklı kontroller ise aynı bölgede yaşayan ve alerjisi olmayan nanotopik kişilerdir.","Çalışma, hastaların subkutan immünoterapi aldığı mevsim öncesi Aralık 2015 ve Ocak 2016 arasında başlamıştır."]},"beginTime":690,"endTime":786,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=690&ask_summarization=1"},{"index":8,"title":"Hastaların Demografik Verileri","list":{"type":"unordered","items":["Hastaların yaşı 19-36 yaş arasında, 5'i kadın 7'si erkek olup, sağlıklı kontrollerin yaş medyanı 35'tir.","Hastaların 13'ünde alerjik rinit, 8'inde astım eşlik ederken, hepsinin deri prick testi pozitif saptanmıştır.","Total IgE seviyelerinin medyan değeri 106-280-274 arasında, PHL-1 ve PHL-5 spesifik IgE'nin medyan değeri 1,5-68,9 arasında değişmektedir."]},"beginTime":786,"endTime":848,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=786&ask_summarization=1"},{"index":9,"title":"Alerjen İmmünoterapi ve Örnek Alma Zamanları","list":{"type":"unordered","items":["Hastaların 10'una huş ağacı poleni ile, 12'sine çimenle alerjen immünoterapisi yapılmış, ancak 2 hasta immünoterapisine cevap vermemiştir.","Alerjen immünoterapisi, mevsimsel alerjik immünoterapinin uygulandığı, Ocak-Kasım 2015 ve Ocak-2016 arasında ve sonraki iki yılda da aynı formatta tedaviler alınmıştır.","Örnekler sıfır noktasında (immünoterapi başlamadan hemen önce), 3. ayda (huş ağacı polenin sezon pikinde), 6. ayda (çimen polenli sezon pikinde) ve 12. ayda (mevsim dışı dönemde) alınmıştır."]},"beginTime":848,"endTime":943,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=848&ask_summarization=1"},{"index":10,"title":"Laboratuvar Çalışmaları ve İstatistiksel Yöntemler","list":{"type":"unordered","items":["Kan örnekleri Inter Spital Bern'de toplanıp İsviçre Alerji ve Araştırma Enstitüsü'ne gönderilmiş, demetri ile boyama ve çalışmaları yapılmıştır.","İmmünoterapiye klinik yanıt olarak IACI kılavuzlarına göre değerlendirme yapılmış, kombine semptom ve ilac skorları örnekleme ile birlikte önceki sezonda ve her bir çalışma ziyaretinde doktorun ofisinde CSMS anketleri ile kaydedilmiştir.","Plazmadaki spesifik IgE'ler immünocap yöntemi kullanılarak ölçülmüş, flotometride hücreler markerlerine göre gruplara ayrılmış ve istatistiksel olarak GraphD Prizin 7 yazılımı kullanılmıştır."]},"beginTime":943,"endTime":1064,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=943&ask_summarization=1"},{"index":11,"title":"Bulgular","list":{"type":"unordered","items":["Alerjen immünoterapinin inned lenfoid hücrelerinin üç ana ve en iyi karakterize edilmiş alt grubunun (tip 1, tip 2, tip 3) frekans ve mutlak sayıları üzerine etkisi araştırılmıştır.","Altı ve oniki aylık zaman noktalarında in lenfoid tip 1'lerin sıklık ve sayılarında artış, tip 2'lerin sıklığında ise oniki aydan itibaren azalma gözlenmiş, tip 3'lerin sıklığı da oniki ay sonra azalmıştır.","Huş ağacı poleni sezonunda alerjen immünoterapinin birinci ve üçüncü yılı arasında in lenfoid tip 1'lerin sıklığında bir değişiklik bulunmamış, ancak altı ile otuz aylık zaman noktalarında kim polen mevsiminde in lenfoid tip 3'lerin sıklığında hafif artış olmuştur."]},"beginTime":1064,"endTime":1196,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1064&ask_summarization=1"},{"index":12,"title":"Alerjen İmmünoterapisi ve İn-Lenfoid Hücreler","list":{"type":"unordered","items":["Alerjen immünoterapiden sonra ilk bir yıl boyunca in-lenfoid alt kümelerinin sıklık ve sayı değerleri değerlendirilmiş, sağlıklı kontrollerle karşılaştırılmıştır.","Alerjisi olan hastalarda in-lenfoid tip bir sıklığı başlangıçta daha düşük, ancak 12 aylık tedaviden sonra hastalarla kontrol arasında farklılık bulunmamıştır.","İn-lenfoid tip iki sıklığı başlangıçta ve 6 ayda kontrollere göre daha yüksek, ancak 12 ay sonrasında hastalar ve kontroller eşit sıklığa gelmiştir."]},"beginTime":1209,"endTime":1282,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1209&ask_summarization=1"},{"index":13,"title":"İn-Lenfoid Tiplerin Fenotipsel Değişiklikleri","list":{"type":"unordered","items":["Klasik kapılama ile yeni tanımlanan alt grupların nicelleştirilmesiyle in-lenfoid tip bir ve tip üçlerin fenotiplerinde ilgi çekici değişiklikler zamanla fark edilmiştir.","Alerjen immünoterapi, daha yüksek CD25 ekspresyonuna sahip in-lenfoid tip bir kümelerinin sayısının artışa sebep olmuştur.","Altı aylık zaman noktasında CD127 pozitif CD25 iki pozitif in-lenfoid hücrelerin sıklığında önemli bir artış gözlenmiş, ancak CD127 iki pozitif CD25 pozitif in-lenfoid tip birlerin sıklığında başlangıca göre azalma izlenmiş."]},"beginTime":1282,"endTime":1364,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1282&ask_summarization=1"},{"index":14,"title":"İn-Lenfoid Tip Üç Alt Popülasyonları","list":{"type":"unordered","items":["Alerjisi olan bireylerdeki in-lenfoid tip üç alt popülasyonların imzası başlangıçta daha az karmaşık ve kontrollerinkinden önemli ölçüde farklıydı.","Alerjen immünoterapisinin başlanmasından sonra 3. ayda ve 6. ayda CD127, CD25 pozitif iki pozitif artışı ve C2 pozitif düşüşü ile ilişkili olarak in-lenfoid tip üç kümelerinde bir artış olmuştur.","Çalışma verileri, alerjen immünoterapinin dolaşımdaki in-lenfoid tip iki ve tip üçlerin sayısını, in-lenfoid tip birlerin sayısı artması lehine sınırlandırdığını göstermektedir."]},"beginTime":1364,"endTime":1465,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1364&ask_summarization=1"},{"index":15,"title":"Natural Killer Hücreler","list":{"type":"unordered","items":["Alerjen immünoterapi uygulanan alerji hastalarında doğal killer hücrelerinin sıklığında bireysel varyasyonlar nedeniyle bir farklılık gözlenmemiştir.","Alerjisi olmayan bireyler bu mevsimi boyunca hem CD65 parlak hem de CD65 sönük NK hücrelerinin frekansında önemli bir düşüş göstermiştir.","Alerjen immünoterapisi NK hücrelerinin sistemik dağılımını etkilemiyor, bu nedenle dolaşımdaki NK hücrelerinin alerjenlere karşı yeniden indiklenen toleransta minör bir rol oynayabileceği düşünülmektedir."]},"beginTime":1465,"endTime":1557,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1465&ask_summarization=1"},{"index":16,"title":"Monositler","list":{"type":"unordered","items":["Klasik monositlerde CD14-16 pozitif monositlerde 3 aydan itibaren bir düşüş gözlenmiş ve bu düşüş 6. ayda daha da belirginleşmiştir.","Alerjen immünoterapi sırasında intermediate CD14 pozitif, CD2 pozitif, 16 pozitif monositlerin sıklığında sabit bir artış gözlenmiş ve bu 12 ayda maksimuma ulaşmıştır.","Alerjen immünoterapinin in-lenfoid alt kümeleri üzerindeki etkilerinin aksine, farklı monosit gruplarının bileşimi üzerindeki etkileri zaman içinde daha az kararlı olmaktadır."]},"beginTime":1557,"endTime":1648,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1557&ask_summarization=1"},{"index":17,"title":"Monositlerin Heterojenliği","list":{"type":"unordered","items":["Alerjen immünoterapi hastalarında ve sağlıklı kontrollerde non-k monositlerin karmaşıklığında bir değişiklik izlenmemiş, ancak HLA-D ekspresyonunda bir artış ve CD141'in daha kararlı ekspresyonu izlenmiştir.","Intermediate monositlerde HLA-D pozitif kümelerde azalma izlenirken, klasik monositlerde 12. ayda HLA-D pozitif CD141 pozitif-negatif olan grupta bir genişleme görülmüştür.","HLA-D ekspresyonunda 3 aydan 12. aya hafif bir azalma ve CD141 ekspresyonunda 6 aydan 12. aya önemli bir azalma bulunmuştur."]},"beginTime":1648,"endTime":1708,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1648&ask_summarization=1"},{"index":18,"title":"Alerjen İmmünoterapi Sürecinde Monosit Değişiklikleri","list":{"type":"unordered","items":["Alerjen immünoterapi sırasında, daha düşük kladr ekspresyona sahip kümelerin genişlemesiyle intermidite monosit sayısında artış gözlemlenmiştir.","Non-classic proflamatuar monositlerdeki azalmayı tanımlayan bu hücrelerin sıklığındaki artışla birlikte, intermediate monositlerde HLA-D ekspresyondaki azalma, anti-inflamatuar tolojenik fena tiplere doğru bir kaymayı yansıtabilir.","Alerjen immünoterapi seyri sırasında monositler pro-inflamatuar tipten anti-inflamatuar tipe doğru kayar."]},"beginTime":1716,"endTime":1763,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1716&ask_summarization=1"},{"index":19,"title":"Dantetik Hücrelerin Değişiklikleri","list":{"type":"unordered","items":["Periferik kanda dantetik hücre alt gruplarına analiz edildiğinde, üç aya kıyasla altı ve oniki aylık zaman noktalarında plazmasteroid dantetik hücre sıklığında artış izlenmiş.","Alerjen immünoterapi sırasında CD1C pozitif miyeloid antik hücrelerin ve yeni hücrelerin sıklığında ve sayılarında önemli bir azalma gözlemlenmiştir.","CD1C pozitif miyeloidler üç aylık alerjen immünoterapiden sonra hatta altı aydan sonra önemli ölçüde azalmış, ancak CD141 pozitif milad dantetik hücrelerin sayısında gözle çarpan bireysel farklılıklar göstermiştir."]},"beginTime":1763,"endTime":1829,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1763&ask_summarization=1"},{"index":20,"title":"Sezonel Değişimler","list":{"type":"unordered","items":["İlk yılın polen sezonunda dantetik hücrelerin birleşiminde alerjen immünoterapinin neden olduğu değişiklikler sonraki sezonlarda modifiye edilmiş gibi görülmüştür.","Üç yıl polen sezonunda alerji immünoterapisinden sonraki üç aya class'ta daha düşük plazmostatik hücre sıklığı bulunmuş, ancak CD1C pozitif yel hücrelerinin sıklığı ilk bir yılda gözlemlenen seviyelerle karşılaştırılabilir düzeyde kalmıştır.","Üç yıl huş ağacı poleni sezonunda CD141 pozitif miyeli hücrelerin sıklığı önemli ölçüde azalmış, çimen poleni sezonunda birazcık artış göstermiş ama yine de ilk yılın değerlerine göre çok daha düşük kalmıştır."]},"beginTime":1829,"endTime":1875,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1829&ask_summarization=1"},{"index":21,"title":"Kontrollerle Karşılaştırma","list":{"type":"unordered","items":["Analiz edilen her zaman noktasında kontrollerle hastalar karşılaştırıldığında, ilk başta sağlıklı kontrollerde daha yüksek plazma sıklığı gözlenirken, oniki ayda hastalardaki plazma sıklığı ve artış, sağlıklı kontrollerde azalmadan kaynaklı resim tersine dönüyor.","Alerjisi olan hastalarda üç, altı ve oniki aylık zaman noktalarında CD1C pozitif miyeloid endritik hücrelerde sağlıklı kontrollere göre daha düşük sıklıkta olduğu gözleniyor.","Alerjisi olan hastalar aynı zaman noktalarında sağlıklı kontrollerdeki sıklığa göre alerjin imminoterapisinden başlamasından altı ve oniki ay sonra önemli ölçüde daha yüksek CD141 pozitif miyeloid antik hücre sıklığı sergiliyor."]},"beginTime":1875,"endTime":1923,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1875&ask_summarization=1"},{"index":22,"title":"TSN Analizi Sonuçları","list":{"type":"unordered","items":["TSN analizi ile hem alerjisi olan hastalarda hem kontrollerde CD1C pozitif mi antik hücrelerinin başlangıçta para olarak heterojen olduğunu ve üç ayrı popülasyonda kümelendiğini gösteriyor.","CD1C pozitif miyeli hücreler ve bu kümelerin karmaşıklığı oldukça farklı, CD1C ve HDR ekspresyonu ile ilişkilendirilmiş alerjen immünoterapi sırasında CD mili antik hücrelerin karmaşıklığı azalırken, bazı kontrollerde bu karmaşıklık artıyor.","Plazmatik hücreler ve CD141 pozitif miyaletitik hücreler başlangıçta her bir alt grup için yalnızca bir kim oluşturmuş ve alerjen immünoterapi sırasında da sabit kalmış."]},"beginTime":1923,"endTime":1975,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1923&ask_summarization=1"},{"index":23,"title":"Genel Sonuçlar","list":{"type":"unordered","items":["Genel olarak alerjen immünoterapinin plazma entetik hücrelerin birleşiminde önemli bir değişiklik olmaksızın plazmasteroid detetik hücrelerde önemli bir artışa neden olduğu bulunmuş.","Alerjen immünoterapi sırasında CD1C tetik hücrelerinin sıklığında bir düşüş gözlemlenmiş, geç zaman noktalarında CD141 pozitif miyeloid antik hücrelerde hafif bir artış bulunmuş.","Dantetik hücrelerin heterojenli inn lenfoid hücreler ve monositlerinkinden daha az karmaşık görünmekte, bu da dantritik hücre alt gruplarının dağılımında alerjen immünoterapi kaynaklı değişikliklerin onların regülatuar düzenleyici potansiyellerini artırdığını gösteriyor."]},"beginTime":1975,"endTime":2034,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=1975&ask_summarization=1"},{"index":24,"title":"Çalışmanın Önemi","list":{"type":"unordered","items":["İnsanlarda alerjenlere karşı bağışıklık tolerans mekanizmaları, alerjen immünoterapi de dahil olmak üzere çeşitli modeller kullanılarak incelenmiştir.","İnna lenfoid hücreler, monosit ve makrofajlar dantetik hücrelerde eğitilmiş bağışıklık mekanizmalarının anlaşılmasındaki son gelişmeler, inte lenfoid hücrelerin veya dentik hücrelerin rektüel işlevlerinin anlaşılması, bu hücrelerin alt gruplarındaki değişikliklerin, immün toleransın indüksiyon açısından daha ayrıntılı olarak incelenmesi gerektiğini ortaya koymuştur.","Bu çalışma, alerjen immünoterapinin sistemik doğal immün yanıtı dinamik değişikliklere neden olduğunu, özellikle doğal immün hücrelerin artan immün regülatörleri ile ilişkili değişikliklerini göstermiş ve gözlemlenen değişimlerin train tolerans eğitilmiş toleransı kolaylaştıran mekanizmaların temelini oluşturabilir."]},"beginTime":2034,"endTime":2110,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=2034&ask_summarization=1"},{"index":25,"title":"Başarılı Alerjen İmmünoterapisi","list":{"type":"unordered","items":["Başarılı bir alerjenin mioterapisi, alerjik semptomlarla beraber ilaç ihtiyacında azalma ile eş zamanlı olarak proenflamatuar hücrelerde azalma ile birlikte anti-inflamatuar popülasyonunda artma olarak tanımlanır.","Tip iki inflamasyon alerjik hastalığın ayırt edici bir özelliğidir ve T-helper-iki efektör hücreleri tarafından düzenlenir, ilgili stokinler ise interlekin dört eksi beş, dokuz ve onüç'tür.","Artan sayıda kanıt, innete lenfoid tip iki'lerin tip iki inflamasyonunu desteklediğini göstermektedir ve bu nedenle inte- lenfoid tip iki'lerin stackin ekspresyon modellerinde efektör T iki hücrelerini yansıttığı kabul edilir."]},"beginTime":2110,"endTime":2155,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=2110&ask_summarization=1"},{"index":26,"title":"İnna Lenfoid Tip İki Hücrelerin Özellikleri","list":{"type":"unordered","items":["Alerjen eğitilmiş in- lenfoid tip iki hücrelerin inflamasyonun çözülmesinden sonra uzun süre varlığının devam ettiği ve tekrarlayan alerjen maruziyetini eğitimsiz naif in lenfoit tip iki'lerden daha güçlü bir şekilde yanıt verdiği gösterilmiştir.","İnna lenfoid tip iki'lerin efektör fonksiyonlarının lokal inflamasyonla ilişkili olmasına rağmen, alerjen yüklemesinden sonra periferde gösterilmiş hızlı indüksiyonu onların gene eğitimini, bağışıklıklarını düşündürmüş.","Bu durum, başlangıçta ve polen mevsiminde alerjisi olan kişilerde yüksek olan alerjen immunoterapi ile azalıp sonunda sağlıklı kontrollerde gözlemlenen seviyelere düşen dolaşımdaki inni- lenfoid iki sıklığını açıklar."]},"beginTime":2155,"endTime":2256,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=2155&ask_summarization=1"},{"index":27,"title":"İnna Lenfoid Tip Bir ve Tip Üç Hücrelerin Değişiklikleri","list":{"type":"unordered","items":["Bugüne kadar, alerjik inflamasyonda dolaşımdaki innede lenfoid tip bir'lerin ve tip üç'lerin rolü belirsizliğini korudu.","Bu çalışmada, alerjen immunoterapiden sonra tip bir ve tip üç'lerin sıklığının ve heterojenliğin değiştirildiği gösteriliyor.","İnna lenfoid tip bir kümesi içinde yeni bir CD-25 lenfoid tip bir kümesi genişlemesi bulunuyor ve tedavi sırasında yeni bir CD127 pozitif, CD25 iki pozitif CD pozitif in lenfoid tip üç kümesinin ortaya çıktığı gözlemleniyor."]},"beginTime":2256,"endTime":2300,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=2256&ask_summarization=1"},{"index":28,"title":"Alerjen İmmünoterapisinin Dolaşımdaki Monositlerin Değişimi","list":{"type":"unordered","items":["Alerjen immünoterapisi, dentetik hücrelerin tonin fenaipini indirerek regülatuar T hücrelerinin indüksiyonuna ve T hücrelerinin azalmasına yol açabilir.","Düşük HD ekspresyona sahip monosit kümelerinde alerjen immünoterapi kaynaklı bir artış kaydedilirken, yüksek HD ekspresyon seviyesi monosit aktivasyonu ve proflamatuar fonksiyonlarla ilişkilidir.","Periferden alınan NANC aktive bir fenotive ve inflamatuar özelliklere sahip monositler, alerjisi olan bireylerde lokal inflamatuar yanıtların desteklenmesinde önemli oyunculardır."]},"beginTime":2312,"endTime":2370,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=2312&ask_summarization=1"},{"index":29,"title":"Monosit Alt Popülasyonlarının Değişimi","list":{"type":"unordered","items":["Intermediate monositler pro-inflamatuar TNF ve interlokin 1-betanın azaltılmış ekspresyonu ile anti-inflamatuar özelliklere sahip olup, lenf düğümlerindeki naif T hücrelerini antijen sunma kapasitelerini azaltarak daha tolerjenik hücreler olarak hizmet etmektedirler.","Alerjen immünoterapinin neden olduğu intermediate monositlerdeki artışa ve NANC monositlerdeki azalmaya doğru kayma, lokal inflamasyonu sınırlamak ve alerjenleri lokal olarak indüklenen toleransı desteklemek için sistemik yanıtı gösterebilir."]},"beginTime":2370,"endTime":2415,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=2370&ask_summarization=1"},{"index":30,"title":"Plazmastoid Dentritik Hücrelerin Değişimi","list":{"type":"unordered","items":["Plazmastoid dentritik hücreler, lokal mikro-çevresel değişikliklere duyarlı olan olgunlaşmamış veya yarı olgun fenotipli heterojen bir hücre alt grubunu temsil eder ve enflamatuar mediatörler ve antijenlerle uyarıldıktan sonra olgunlaşma süreci başlatılır.","Plazmastoid entetik hücreler düşük seviyelerde HDR ve kostüm simülatör molekülleri ekspress ederler ve T hücresine veya toleransına yol açar.","Başlangıçta alerjisi olan bireylerde dolaşımdaki plazmatikoid antisik hücrelerinin daha düşük sıklığı, daha düşük tolojenik potansiyellerini yansıtmaktadır ve eğitimli tolerans ile birlikte bu düşük toolojik potansiyel hedeflenir ve etkili bir biçimde arttırılır."]},"beginTime":2415,"endTime":2516,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=2415&ask_summarization=1"},{"index":31,"title":"Çalışmanın Sonuçları ve Önemi","list":{"type":"unordered","items":["Alerjen immunoterapinin dolaşımdaki ne lenfoid hücreleri, monositlerin ve dentritik hücre alt popülasyonlarının kompozisyonda ve fenotipi de zamana bağlı değişiklikleri indiklediği gösterilmiştir.","Çalışma verileri, proinflamatuar hücrelerde bir azalma ile tolerans indiklenen alt gruplara doğru geçişi invive olarak göstermektedir.","Bu durum, alerjen immunoterapi ile indiklenentimli bir toleransın varlığını ve dolaşımdaki immün hücrelerinin yanıtlarını ayrıntılı değerlendirmesine olan ihtiyacı gösterir."]},"beginTime":2516,"endTime":2553,"href":"/video/preview/13181800838816424335?channelId=d3d3LnlvdXR1YmUuY29tO3VuZGVmaW5lZA%3D%3D&how=tm&parent-reqid=1754726700186257-6217460510645381983-balancer-l7leveler-kubr-yp-klg-303-BAL&text=Etimesgut+Spor+Kul%C3%BCb%C3%BC&t=2516&ask_summarization=1"},{"index":32,"title":"Önemli Noktalar","list":{"type":"unordered","items":["Alerjen immünoterapi sırasında in-lenfoid tip 2'ler ve 3'ler down regle edilirken, tip 1'ler aprele edilir.","Alerjen immünoterapinin neden olduğu in-lenfoid tip 2'lerin sistemik düşüşü ve in-lenfoid tip 1'lerin artışı alerjen immünoterapinin üç yıla kadar sabit kalır.","Alerjen immünoterapi süresince daha yüksek CD ekspresyona sahip minet lenfoid tip 1 kümeleri artmıştır ve ilk yılda dolaşımdaki monositlerin pro-inflamatuar fenoti anti-inflamatuar yani non-classic ve intermediaternatie geçişini 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